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J Environ Public 2012:835059 Hotchkiss RS, Moldawer LL, Opal SM, Reinhart K, Turnbull IR, Vincent JL (2016) Sepsis and septic shock

The fact that methylation is responsible for regulating the expression of miRNAs was discovered through a study on a colonic cancer cell line, where the loss of DNMTs was able to reactivate silenced miRNAs, promoting tumor growth [12, 85]